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Oral nicotine pouches can contain high levels of nicotine, and a study from 2022 found that sales of oral nicotine pouches containing the highest nicotine concentration (8 mg) increased faster than sales of pouches with a lower nicotine concentration (6, 4, or 3 mg), raising concerns about the addictiveness of these products

Most notably, polycyclic hydrocarbons in tobacco cigarette smoke induce expression of CYP1A2, which is essential for the breakdown of the antidepressant fluvoxamine (161)

Atomizers last about 3-6 weeks (on average) and replacements are one of the recurring expenses associated with electronic cigarettes

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